Over the past decade, there has been an unprecedented international focus on improved
quality and availability of medical care, which has reignited interest in clinical automation …

We are witnessing a notable rise in the translational use of information technology and
control systems engineering tools in clinical practice. This paper empowers the computer …

Purpose We evaluated the feasibility and robustness of three methods for propofol-to-
bispectral index (BIS) post-operative intensive care sedation, a manually-adapted target …

It can be said that when inducing and maintaining anes-thesia, anesthesiologists apply a
reactive approach. They select initial doses on the basis of a variety of considerations …

The presence of artifacts plays a crucial role in automatic sedation systems and may
introduce variable time delays (TDs) in the closed-loop-control structures. This paper …

In this paper, we present results with clinical data to enable a 2x2 input–output multivariable
patient model for hypnosis and analgesia. Nonlinear multi-drug interaction models are …

In this paper we propose an inversion-based methodology for the computation of a
feedforward action for the propofol intravenous administration during the induction of …

This paper discusses a possibility to simplify the number of parameters in the Hill curve by
exploiting special mathematical functions. This simplification is relevant when adaptation is …

Many regulatory loops in drug delivery systems for depth of anesthesia optimization problem
consider only the effect of the controller output on the patient pharmacokinetic and …

The increasing gap between modern chip frequencies and test clock frequencies provided
by external test equipment, makes at-speed delay testing a challenge. We present a novel …