Selenium and its' role in the maintenance of genomic stability

LR Ferguson, N Karunasinghe, S Zhu… - … research/fundamental and …, 2012 - Elsevier
Selenium (Se) is an essential micronutrient for humans, acting as a component of the
unusual amino acids, selenocysteine (Se-Cys) and selenomethionine (Se-Met). Where Se …

Impact of dietary selenium intake on cardiac health: experimental approaches and human studies

S Tanguy, S Grauzam, J de Leiris… - Molecular nutrition & …, 2012 - Wiley Online Library
Selenium, a dietary trace mineral, essential for humans and animals, exerts its effects mainly
through its incorporation into selenoproteins. Adequate selenium intake is needed to …

Selenistasis: epistatic effects of selenium on cardiovascular phenotype

J Joseph, J Loscalzo - Nutrients, 2013 - mdpi.com
Although selenium metabolism is intricately linked to cardiovascular biology and function,
and deficiency of selenium is associated with cardiac pathology, utilization of selenium in …

MicroRNA expression profiles in rats with selenium deficiency and the possible role of the Wnt/β‑catenin signaling pathway in cardiac dysfunction

Y Xing, Z Liu, G Yang, D Gao… - … journal of molecular …, 2015 - spandidos-publications.com
Selenium deficiency is a causative factor in heart failure and microRNAs (known as miRNAs
or miRs) play an important role in numerous cardiovascular diseases. However, the …

Effects of melatonin and adrenomedullin in reducing the cardiotoxic effects of doxorubicin in rats

G Durdagi, DY Pehlivan, EO Oyar, SA Bahceci… - Cardiovascular …, 2021 - Springer
The main disadvantage of doxorubicin (DOX) is that it has cardiotoxic side effects. Our aim is
to evaluate the cardioprotective effects of adrenomedullin (ADM) and to compare these …

Mitochondrial dysfunction associated with doxorubicin

C Guven, Y Sevgiler, E Taskin - Mitochondrial Dis, 2018 - books.google.com
Cancer prevalence is scaling up each year. Anthracycline groups are still the best
chemotherapeutic agent. The most popular anticancer drug in the group is doxorubicin …

Selenium attenuates high glucose-induced ROS/TLR-4 involved apoptosis of rat cardiomyocyte

ZW Liu, HT Zhu, KL Chen, C Qiu, KF Tang… - Biological trace element …, 2013 - Springer
The potential mechanism of high glucose-induced cardiomyocyte apoptosis and selenium's
protective effects were investigated in this study. Myocytes isolated from neonate rats were …

The restoration of kidney mitochondria function by inhibition of angiotensin-II production in rats with acute adriamycin-induced nephrotoxicity

E Taskin, K Ozdogan, E Kunduz Kindap, N Dursun - Renal Failure, 2014 - Taylor & Francis
Adriamycin (ADR) is commonly used for many solid tumor treatments. Its clinical utility is,
however, largely limited by the adverse reactions, are known to be nephrotoxic. The …

The protection of selenium on adriamycin-induced mitochondrial damage in rat

E Taskin, N Dursun - Biological trace element research, 2012 - Springer
Although adriamycin (ADR) exhibits high anti-tumor efficacy in vitro, its clinical use in cancer
chemotherapy is limited due to its high renal toxicity. This study investigated the mechanism …

Counteraction of apoptotic and inflammatory effects of adriamycin in the liver cell culture by clinopitolite

H Yapislar, E Taskin, S Ozdas, D Akin… - Biological trace element …, 2016 - Springer
Growing evidence has been reported on adriamycin (ADR) hepatotoxicity in literature.
Hepatotoxicity caused by the use of drugs has a serious undesirable effect in the cure of …