Roles for retrotransposon insertions in human disease
DC Hancks, HH Kazazian - Mobile DNA, 2016 - Springer
Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …
Restricting retrotransposons: a review
JL Goodier - Mobile DNA, 2016 - Springer
Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
J Lucifora, Y Xia, F Reisinger, K Zhang, D Stadler… - Science, 2014 - science.org
Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
The APOBEC protein family: united by structure, divergent in function
JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …
have diverse and important functions in human health and disease. These proteins have an …
[HTML][HTML] APOBECs and virus restriction
RS Harris, JP Dudley - Virology, 2015 - Elsevier
The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness
During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be
more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by …
more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by …
[HTML][HTML] Methods and applications of CRISPR-mediated base editing in eukaryotic genomes
The past several years have seen an explosion in development of applications for the
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …
Alu elements: know the SINEs
P Deininger - Genome biology, 2011 - Springer
Alu elements: know the SINEs | Genome Biology Skip to main content SpringerLink Account
Menu Find a journal Publish with us Track your research Search Cart 1.Home 2.Genome …
Menu Find a journal Publish with us Track your research Search Cart 1.Home 2.Genome …
The influence of LINE‐1 and SINE retrotransposons on mammalian genomes
SR Richardson, AJ Doucet, HC Kopera… - Mobile DNA …, 2015 - Wiley Online Library
Transposable elements (TEs) or “jumping genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
APOBEC mutagenesis is a common process in normal human small intestine
APOBEC mutational signatures SBS2 and SBS13 are common in many human cancer
types. However, there is an incomplete understanding of its stimulus, when it occurs in the …
types. However, there is an incomplete understanding of its stimulus, when it occurs in the …