S phingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol
backbones which are synthesized in the ER from nonsphingolipid precursors. Modification …

Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …

Background & Aims Epigenetic silencing of tumor suppressor genes contributes to the
pathogenesis of hepatocellular carcinoma (HCC). To identify clinically relevant tumor …

Sphingolipids are an important class of lipid molecules that play fundamental roles in our
cells and body. Beyond a structural role, it is now clearly established that sphingolipids …

Sphingolipids (SFs) represent a large class of lipids playing diverse functions in a vast
number of physiological and pathological processes. Sphingomyelin (SM) is the most …

Programmed cell death, or apoptosis, is a complex process whereby eukaryotic cells react to
physiologic or pathophysiologic stimuli by undergoing genetically programmed suicide …

The plasma membrane (PM) is a major resource for production of bioactive lipids and
contains a large proportion of the cellular sphingomyelin (SM) content. Consequently, the …

Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase
(NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can …

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential
bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase …

Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …