Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases

M Lin, N Liu, Z Qin, Y Wang - Acta Pharmacologica Sinica, 2022 - nature.com
Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration
and neurodegenerative diseases. Accumulating evidence shows multiple links between …

Mitochondrial dysfunction: roles in skeletal muscle atrophy

X Chen, Y Ji, R Liu, X Zhu, K Wang, X Yang… - Journal of Translational …, 2023 - Springer
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

GZ Zhang, MQ Liu, HW Chen, ZL Wu, YC Gao… - Cell …, 2021 - Wiley Online Library
Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the
spine. A series of factors, such as inflammation, oxidative stress and mechanical stress …

The functional impact of mitochondrial structure across subcellular scales

B Glancy, Y Kim, P Katti, TB Willingham - Frontiers in physiology, 2020 - frontiersin.org
Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Inflammatory response of nanoparticles: mechanisms, consequences, and strategies for mitigation

M Summer, R Ashraf, S Ali, H Bach, S Noor, Q Noor… - Chemosphere, 2024 - Elsevier
Numerous nano-dimensioned materials have been generated as a result of several
advancements in nanoscale science such as metallic nanoparticles (mNPs) which have …

Oxidative stress is the pivot for PM2. 5-induced lung injury

T Hou, L Zhu, Y Wang, L Peng - Food and Chemical Toxicology, 2024 - Elsevier
Abstract Fine particulate matter (PM2. 5) is a primary air pollutant recognized worldwide as a
serious threat to public health. PM2. 5, which has a diameter of less than 2.5 μm, is known to …

Mitochondrial quality surveillance as a therapeutic target in myocardial infarction

H Zhu, S Toan, D Mui, H Zhou - Acta physiologica, 2021 - Wiley Online Library
Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. As
mitochondrial dysfunction critically contributes to the pathogenesis of MI, intensive research …

Hydrogen, a novel therapeutic molecule, regulates oxidative stress, inflammation, and apoptosis

Y Tian, Y Zhang, Y Wang, Y Chen, W Fan… - Frontiers in …, 2021 - frontiersin.org
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2
inhalation has the therapeutic effects in many animal studies and clinical trials, and its …

BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease

Y Li, W Zheng, Y Lu, Y Zheng, L Pan, X Wu… - Cell Death & …, 2021 - nature.com
Mitophagy is a highly conserved cellular process that maintains the mitochondrial quantity
by eliminating dysfunctional or superfluous mitochondria through autophagy machinery. The …

Bioinspired nanogels as cell-free DNA trapping and scavenging organelles for rheumatoid arthritis treatment

H Zhu, B Kong, J Che, Y Zhao… - Proceedings of the …, 2023 - National Acad Sciences
Excessive cell-free DNA (cfDNA) in the serum and synovium is considered a causative factor
of rheumatoid arthritis (RA). Thus, cfDNA scavenging by using cationic polymers has been …