Metabolic bone disease is a common complication of chronic kidney disease (CKD) and is
part of a broad spectrum of disorders of mineral metabolism that occur in this clinical setting …

Cardiovascular events are the most frequent cause of death in patients with chronic renal
failure (1–2). Heterotopic calcification of blood vessel walls occurs frequently with advanced …

This article discusses different aspects concerning classification/nomenclature, biochemical
properties and pathophysiological roles of 'reactive oxygen species'(ROS) which are pivotal …

Serum calcium levels are regulated by the action of parathyroid hormone (PTH). Major
drivers of PTH hypersecretion and parathyroid cell proliferation are the hypocalcemia and …

The identification of the calcium-sensing receptor (CaSR) and the clarification of its role as
the major regulator of parathyroid gland function have important implications for …

Small decreases in serum Ca2+ and more prolonged increases in serum phosphate (Pi)
stimulate the parathyroid (PT) to secrete parathyroid hormone (PTH), and 1, 25 (OH) 2D3 …

p21 WAF1 and TGF-α mediate parathyroid growth arrest by vitamin D and high calcium.
Background High dietary phosphorus (P) worsens uremia-induced parathyroid (PT) …

Uremic secondary hyperparathyroidism is a multifactorial and complex disease often
present in advanced stages of chronic kidney disease. The accumulation of phosphate, the …

1, 25 (OH) 2 D 3 antiproliferative properties are widely known. However, the molecular
bases of these properties are only partially elucidated. Since 1, 25 (OH) 2 D 3 effectively …

Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with
advanced secondary hyperparathyroidism. Background In uremic patients with secondary …