A review of chemical signaling pathways in the quorum sensing circuit of Pseudomonas aeruginosa

K Vadakkan, AK Ngangbam, K Sathishkumar… - International Journal of …, 2024 - Elsevier
Pseudomonas aeruginosa, an increasingly common competitive and biofilm organism in
healthcare infection with sophisticated, interlinked and hierarchic quorum systems (Las, Rhl …

Current therapies in treatment and prevention of fracture wound biofilms: why a multifaceted approach is essential for resolving persistent infections

KA Blanchette, JC Wenke - Journal of bone and joint infection, 2018 - jbji.copernicus.org
Traumatic orthopedic injuries, particularly extremity wounds, are a significant cause of
morbidity. Despite prophylactic antibiotic treatment and surgical intervention, persistent …

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

MF Debets, OY Tastan, SP Wisnovsky… - Proceedings of the …, 2020 - National Acad Sciences
Protein glycosylation events that happen early in the secretory pathway are often
dysregulated during tumorigenesis. These events can be probed, in principle, by …

A catalytic enantioselective stereodivergent aldol reaction

MA Rahman, T Cellnik, BB Ahuja, L Li, AR Healy - Science advances, 2023 - science.org
The aldol reaction is among the most powerful and strategically important carbon–carbon
bond–forming transformations in organic chemistry. The importance of the aldol reaction in …

An Overview on the Chemical N‐Functionalization of Sugars and Formation of N‐Glycosides

R Sangwan, A Khanam… - European Journal of …, 2020 - Wiley Online Library
Its even more than a centennial that the systematic researches of chemical alteration of
sugars have been advancing. Out of all the interest in the field of N‐glycoside has …

N-alkylimidazole derivatives as potential inhibitors of quorum sensing in Pseudomonas aeruginosa

CN Mensah, GB Ampomah, JO Mensah, EN Gasu… - Heliyon, 2022 - cell.com
Antimicrobial resistance is a threat to global public health. Microbial resistance is mediated
by biofilm formation and virulence behavior during infection. Quorum sensing (QS), a cell-to …

N-Acetyl-l-phenylalanine Racemization during TBTU Amidation: An In-Depth Study for the Synthesis of Anti-Inflammatory 2-(N-Acetyl)-l-phenylalanylamido-2-deoxy-d …

E Sturabotti, F Vetica, G Toscano, A Calcaterra… - Molecules, 2023 - mdpi.com
A thorough study on the amidation conditions of N-acetyl-l-phenylalanine using TBTU and
various bases is reported for the synthesis of 2-(N-acetyl)-l-phenylalanylamido-2-deoxy-d …

Synthesis and biological evaluation of novel acyclic and cyclic glyoxamide based derivatives as bacterial quorum sensing and biofilm inhibitors

S Nizalapur, O Kimyon, E Yee… - Organic & …, 2017 - pubs.rsc.org
Bacteria regulate the expression of various virulence factors and processes such as biofilm
formation through a chemically-mediated communication mechanism called quorum …

Tryptophan–glucosamine conjugates modulate tau-derived PHF6 aggregation at low concentrations

A Paul, WH Li, GKK Viswanathan, E Arad… - Chemical …, 2019 - pubs.rsc.org
Glycosylation of amyloidogenic proteins enhances their solubility and reduces propensity for
aggregation. We therefore, prepared tryptophan–glucosamine conjugates to modulate …

Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoproteins

A Zafar, S Sridhar, G Bineva-Todd, A Cioce… - RSC Chemical …, 2024 - pubs.rsc.org
Glycosylation is a ubiquitous modification of proteins, necessitating approaches for its
visualization and characterization. Bioorthogonally tagged monosaccharides have been …