Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases

A Salminen - Journal of molecular medicine, 2021 - Springer
Chronic low-grade inflammation is a common hallmark of the aging process and many age-
related diseases. There is substantial evidence that persistent inflammation is associated …

The diversity of myeloid immune cells shaping wound repair and fibrosis in the lung

L Florez‐Sampedro, S Song, BN Melgert - Regeneration, 2018 - Wiley Online Library
In healthy circumstances the immune system coordinates tissue repair responses in a tight
balance that entails efficient inflammation for removal of potential threats, proper wound …

Stretching impacts inflammation resolution in connective tissue

L Berrueta, I Muskaj, S Olenich, T Butler… - Journal of cellular …, 2016 - Wiley Online Library
Acute inflammation is accompanied from its outset by the release of specialized pro‐
resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local …

Human tolerogenic dendritic cells produce IL‐35 in the absence of other IL‐12 family members

KO Dixon, SW van der Kooij… - European journal of …, 2015 - Wiley Online Library
IL‐35 is a cytokine of the IL‐12 family, existing as a heterodimer of IL‐12p35 and Ebi3. IL‐35
has anti‐inflammatory properties and is produced by regulatory T cells in humans and mice …

Cervical cancer–instructed stromal fibroblasts enhance IL23 expression in dendritic cells to support expansion of Th17 cells

B Walch-Rückheim, R Ströder, L Theobald… - Cancer research, 2019 - AACR
Persistent infection with high-risk human papillomavirus (HPV) is a prerequisite for the
development of cervical cancer. HPV-transformed cells actively instruct their …

Renal fibrosis in precision-cut kidney slices

EGD Stribos, JL Hillebrands, P Olinga… - European journal of …, 2016 - Elsevier
Chronic kidney disease (CKD) is associated with renal fibrosis, a pathological process that
is characterized by excessive accumulation of extracellular matrix proteins resulting in loss …

Tolerogenic effect of mouse fibroblasts on dendritic cells

M Khosravi‐Maharlooei, MR Pakyari, RB Jalili… - …, 2016 - Wiley Online Library
There is controversy about the immunomodulatory effect of fibroblasts on dendritic cells (DC
s). To clarify this issue, in this study, we have evaluated different features of fibroblast …

Properties and immune function of cardiac fibroblasts

MB Furtado, M Hasham - The Immunology of Cardiovascular Homeostasis …, 2017 - Springer
This chapter will discuss the role of cardiac fibroblasts as a target of various immunological
inputs as well as an immunomodulatory hub of the heart through interaction with immune …

Mesenchymal stromal cells in clinical kidney transplantation: how tolerant can it be?

C van Kooten, TJ Rabelink, JW de Fijter… - Current Opinion in …, 2016 - journals.lww.com
This review will discuss the current status of ongoing clinical trials with mesenchymal
stromal cells in kidney transplantation and specifically concentrate on the possibilities and …

MIF family proteins in lung diseases

S Song - 2021 - research.rug.nl
Chronic obstructive pulmonary disease (COPD) and lung cancer constitute an enormous
disease burden in developed countries. Every year, COPD causes more than three million …