Cell death plays an essential role in the development of tissues and organisms, the etiology
of disease, and the responses of cells to therapeutic drugs. Here we review progress made …

Systems biology is an emerging discipline that combines high-content, multiplexed
measurements with informatic and computational modeling methods to better understand …

Reverse phase protein array (RPPA) technology introduced a miniaturized “antigen-down”
or “dot-blot” immunoassay suitable for quantifying the relative, semi-quantitative or …

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that
protein interactions act as sophisticated data processing networks that govern intracellular …

If the large collection of microarray-specific statistical tools was applicable to the analysis of
quantitative shotgun proteomics datasets, it would certainly foster an important advancement …

Recent advances in computer hardware and software have led to the development of
increasingly successful molecular simulations of protein structural dynamics that are intrinsic …

Biomedical research frequently involves performing experiments and developing
hypotheses that link different scales of biological systems such as, for instance, the scales of …

Background: Over the last 10 years, DNA microarrays have achieved a robust analytical
performance, enabling their use for analyzing the whole transcriptome or for screening …

We are all perplexed that current medical practice often appears maladroit in curing our
individual illnesses or disease. However, as is often the case, a lack of understanding, tools …

Computational models of cell signalling are perceived by many biologists to be prohibitively
complicated. Why do math when you can simply do another experiment? Here, we explain …