The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Since the crucial role of the microenvironment has been highlighted, many studies have
been focused on the role of biomechanics in cancer cell growth and the invasion of the …

To divide in a tissue, both normal and cancer cells become spherical and mechanically
stiffen as they enter mitosis. We investigated the effect of oncogene activation on this …

Mutations in RAS are key oncogenic drivers and therapeutic targets. Oncogenic Ras
proteins activate a network of downstream signalling pathways, including extracellular …

The loss of epithelial homeostasis and the disruption of normal tissue morphology are
hallmarks of tumor development. Here, we ask how the uniform activation oncogene RAS …

We study the competition for space between two cell lines that differ only in the expression of
the Ras oncogene. The two cell populations are initially separated and set to migrate …

Cell competition enables normal wildtype cells of epithelial tissue to eliminate mutant cells
expressing activated oncoproteins such as HRas V12. However, the driving force behind …

Tumor emboli—aggregates of tumor cells within vessels—pose a clinical challenge as they
are associated with increased metastasis and tumor recurrence. When growing within a …

Epithelial tissues are highly sensitive to anisotropies in mechanical force, with cells altering
fundamental behaviors, such as cell adhesion, migration, and cell division. 1–5 It is well …

Cell mechanics is a fascinating subject that has witnessed a boost of scientific interest in the
most diverse disciplines. Evidence of its biological relevance is continuously mounting …