The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …

Cyclic mechanical strain produced by pulsatile blood flow regulates the orientation of
endothelial cells lining blood vessels and influences critical processes such as …

A defining hallmark of cancer and cancer development is upregulated angiogenesis. The
vasculature formed in tumors is structurally abnormal, not organized in the conventional …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

Although it is well established that changes in endothelial intracellular [Ca2+] regulate
endothelium-dependent vasodilatory pathways, the molecular identities of the ion channels …

The vascular endothelium plays a vital role during embryogenesis and aging and is a cell
monolayer that lines the blood vessels. The immune system recognizes the endothelium as …

Background: Under physiological conditions, endothelial cells are the main regulator of
arterial tone homeostasis and vascular growth, sensing and transducing signals between …