Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

The development of α‐synuclein immunoreactive aggregates in selectively vulnerable
neuronal types of the human central, peripheral, and enteric nervous systems is crucial for …

Neurodegenerative diseases (NDDs) are characterized by selective dysfunction and loss of
neurons associated with pathologically altered proteins that deposit in the human brain but …

Neurodegenerative diseases are characterised by selective dysfunction and progressive
loss of synapses and neurons associated with pathologically altered proteins that deposit …

To date, there have been few systematic attempts to provide a standard operating procedure
for the neuropathological diagnosis of Parkinson's disease (PD). Pathological examination …

The histopathological hallmark of Parkinson's disease (PD) is the presence of fibrillar
aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent …

Neuronal aggregates of misfolded alpha-synuclein protein are found in the brain and
periphery of patients with Parkinson's disease. Braak and colleagues have hypothesized …

A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain
sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
no longer considered a complex motor disorder characterized by extrapyramidal symptoms …