Molecular mechanisms and cellular functions of cGAS–STING signalling
KP Hopfner, V Hornung - Nature reviews Molecular cell biology, 2020 - nature.com
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Z Zhang, H Zhou, X Ouyang, Y Dong… - Signal transduction and …, 2022 - nature.com
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
L Zhang, X Wei, Z Wang, P Liu, Y Hou, Y Xu, H Su… - Cell Reports, 2023 - cell.com
It is widely known that stimulator of interferon genes (STING) can trigger nuclear factor κB
(NF-κB) signaling. However, whether and how the NF-κB pathway affects STING signaling …
(NF-κB) signaling. However, whether and how the NF-κB pathway affects STING signaling …
Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
The classic mode of STING activation is through binding the cyclic dinucleotide 2′ 3′-
cyclic GMP–AMP (cGAMP), produced by the DNA sensor cyclic GMP–AMP synthase …
cyclic GMP–AMP (cGAMP), produced by the DNA sensor cyclic GMP–AMP synthase …
Signaling by cGAS–STING in neurodegeneration, neuroinflammation, and aging
Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
[HTML][HTML] The cGAS–STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy
PK Oduro, X Zheng, J Wei, Y Yang, Y Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …
exert essential regulatory function in microbial-and onco-immunology through the induction …
Mitochondrial-derived vesicles in metabolism, disease, and aging
T König, HM McBride - Cell Metabolism, 2024 - cell.com
Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool
Stimulator of interferon genes (STING) orchestrates the production of proinflammatory
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
Pandemic democracy: elections and COVID-19
T Landman, LDG Splendore - COVID-19, 2022 - taylorfrancis.com
This article provides an initial assessment of the many risks posed by the COVID-19
pandemic on the conduct of genuine and transparent elections in the world. It begins with …
pandemic on the conduct of genuine and transparent elections in the world. It begins with …
STING trafficking as a new dimension of immune signaling
The cGAS–STING pathway is an evolutionarily conserved immune signaling pathway critical
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …