A Edsjö, HG Russnes, J Lehtiö… - Journal of internal …, 2024 - Wiley Online Library
In the last decades, the development of high‐throughput molecular assays has revolutionised cancer diagnostics, paving the way for the concept of personalised cancer …
Simple Summary Ampullary tumors are rare malignancies of the upper gastrointestinal tract. Histologic, immunohistochemical and, most recently, genomic biomarkers have been used …
LJ Schipper, KG Samsom, P Snaebjornsson… - ESMO open, 2022 - Elsevier
Background In∼ 3%-5% of patients with metastatic disease, tumor origin remains unknown despite modern imaging techniques and extensive pathology work-up. With long diagnostic …
Purpose: The clinical behavior of ampullary adenocarcinoma varies widely. Targeted tumor sequencing may better define biologically distinct subtypes to improve diagnosis and …
Y Song, T Boerner, E Drill, P Shin, S Kumar… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: Intrahepatic cholangiocarcinoma (IHC) is a heterogeneous tumor. The hidden- genome classifier, a supervised machine learning–based algorithm, was used to quantify …
BL Ecker, K Seier, AM Eckhoff, GN Tortorello… - JAMA …, 2024 - jamanetwork.com
Importance Ampullary adenocarcinoma (AA) is characterized by clinical and genomic heterogeneity. A previously developed genomic classifier defined biologically distinct …
N Jurenaite, D León-Periñán, V Donath, S Torge… - Biosystems, 2024 - Elsevier
Abstract In oncology, Deep Learning has shown great potential to personalise tasks such as tumour type classification, based on per-patient omics data-sets. Being high dimensional …
Inferring the cancer-type specificities of ultra-rare, genome-wide somatic mutations is an open problem. Traditional statistical methods cannot handle such data due to their ultra-high …
S Chakraborty, Z Guan, CE Kostrzewa… - Genetic …, 2024 - Wiley Online Library
Numerous studies over the past generation have identified germline variants that increase specific cancer risks. Simultaneously, a revolution in sequencing technology has permitted …