Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for
dissemination, long-term persistence within tissues and virus replication. Viruses enter cells …

Background The current outbreak of pandemic coronavirus disease 2019 (COVID-19)
aggravates serious need for effective therapeutics. Over recent years, drug repurposing has …

Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long
persistence in the host, like all herpesviruses, by way of a latent infection. During latency …

The human cytomegalovirus (HCMV), whose genome is 235±1.9 kbp long, is a common
herpesvirus. However, the functions of many of its genes are still unknown. HCMV is closely …

The establishment of human cytomegalovirus (HCMV) latency and persistence relies on the
successful infection of hematopoietic cells, which serve as sites of viral persistence and …

Reactivation from latency requires reinitiation of viral gene expression and culminates in the
production of infectious progeny. The major immediate early promoter (MIEP) of human …

To effectively defend against microbial pathogens, the host cells mount antiviral innate
immune responses by producing interferons (IFNs), and hundreds of IFN-stimulated genes …

The wide range of disease pathologies seen in multiple organ sites associated with human
cytomegalovirus (HCMV) infection results from the systemic hematogenous dissemination of …

Immunosenescence is an age-related reduction of immune system activity that can be
associated with frailty. This study aimed to compare cytomegalovirus (CMV) and Epstein …

Human cytomegalovirus (HCMV) is a highly prevalent beta-herpesvirus and a significant
cause of morbidity and mortality following hematopoietic and solid organ transplant, as well …