Emerging role of plumbagin: Cytotoxic potential and pharmaceutical relevance towards cancer therapy

SK Tripathi, M Panda, BK Biswal - Food and Chemical Toxicology, 2019 - Elsevier
Plumbagin is a naphthoquinone derived yellow crystalline phytochemical. Plumbagin has a
wide range of biological effects including cytotoxicity against cancer cells both in vitro and in …

Plumbagin: a potential anti-cancer compound

A Roy - Mini reviews in medicinal chemistry, 2021 - ingentaconnect.com
Cancer is a deadly disease, which has significantly increased in both developed and
developing nations. Treatment of cancer utilizing radiotherapy or chemotherapy actuates a …

Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo

HP Lee, PC Chen, SW Wang, YC Fong, CH Tsai… - Journal of Functional …, 2019 - Elsevier
Plumbagin, a naturally occurring naphthoquinone component isolated from the root of
Plumbago zeylanica, reduces angiogenesis in human umbilical vein endothelial cells; …

Angiogenesis inhibitors as therapeutic agents in cancer: Challenges and future directions

Z Lin, Q Zhang, W Luo - European journal of pharmacology, 2016 - Elsevier
Angiogenesis has become an attractive target for cancer therapy since the US Food and
Drug Administration (FDA) approved the first angiogenesis inhibitor (bevacizumab) for the …

Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells

YC Li, SM He, ZX He, M Li, Y Yang, JX Pang, X Zhang… - Cancer Letters, 2014 - Elsevier
Plumbagin (PLB) has shown anti-cancer activity but the mechanism is unclear. This study
has found that PLB has a potent pro-apoptotic and pro-autophagic effect on A549 and H23 …

Anticancer therapeutic potential of genus Diospyros: From phytochemistry to clinical applications—A review

A Rauf, Z Akram, N Hafeez, AA Khalil… - Food Science & …, 2024 - Wiley Online Library
The genus Diospyros has gained significant attention in the scientific community owing to its
diverse bioactivities ascribed to specific bioactive constituents present in different species of …

Quinones derived from plant secondary metabolites as anti-cancer agents

JJ Lu, JL Bao, GS Wu, WS Xu… - Anti-Cancer Agents …, 2013 - ingentaconnect.com
Quinones are plant-derived secondary metabolites that present some anti-proliferation and
anti-metastasis effects in various cancer types both in vitro and in vivo. This review focuses …

Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling

YY Cao, J Yu, TT Liu, KX Yang, LY Yang, Q Chen… - Cell Death & …, 2018 - nature.com
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it
requires novel treatment approaches and effective drugs. In the present study, we found that …

Diospyros, an under-utilized, multi-purpose plant genus: A review

A Rauf, G Uddin, S Patel, A Khan, SA Halim… - Biomedicine & …, 2017 - Elsevier
The genus Diospyros from family Ebenaceae has versatile uses including edible fruits,
valuable timber, and ornamental uses. The plant parts of numerous species have been in …

Epigenetic modulators as therapeutic targets in prostate cancer

I Graça, E Pereira-Silva, R Henrique, G Packham… - Clinical …, 2016 - Springer
Prostate cancer is one of the most common non-cutaneous malignancies among men
worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or …