Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

Sarcopenia is primarily characterized by skeletal muscle disturbances such as loss of
muscle mass, quality, strength, and physical performance. It is commonly seen in elderly …

Background Cellular senescence is a key mechanism that drives age-related diseases, but
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …

Most patients with advanced solid cancers exhibit features of cachexia, a debilitating
syndrome characterized by progressive loss of skeletal muscle mass and strength. Because …

Background & Aims Studies exploring the relationship between muscle fat content and non-
alcoholic fatty liver disease (NAFLD) are scarce. Herein, we aimed to evaluate the …

Background Cachexia is frequent, deadly, and untreatable for patients with pancreatic ductal
adenocarcinoma (PDAC). The reproductive hormone and cytokine Activin is a mediator of …

Patients suffering from chronic heart failure (CHF) show an increased prevalence (~ 20% in
elderly CHF patients) of loss of muscle mass and muscle function (ie sarcopenia) compared …

The transforming growth factor (TGF)-β family is a group of structurally related,
multifunctional growth factors, or ligands that are crucially involved in the development …

Advanced cancer patients exhibit cachexia, a condition characterized by a significant
reduction in the body weight predominantly from loss of skeletal muscle and adipose tissue …

Cachexia is a complex multifactorial syndrome, characterized by loss of skeletal muscle and
fat mass, which affects the majority of advanced cancer patients and is associated with poor …