The trinity of COVID-19: immunity, inflammation and intervention

MZ Tay, CM Poh, L Rénia, PA MacAry… - Nature Reviews …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into …

The molecular virology of coronaviruses

E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival

S Dispinseri, M Secchi, MF Pirillo, M Tolazzi… - Nature …, 2021 - nature.com
Understanding how antibody responses to SARS-CoV-2 evolve during infection may
provide important insight into therapeutic approaches and vaccination for COVID-19. Here …

[HTML][HTML] Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus

B Korber, WM Fischer, S Gnanakaran, H Yoon… - Cell, 2020 - cell.com
A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become
the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies …

Protocol and reagents for pseudotyping lentiviral particles with SARS-CoV-2 spike protein for neutralization assays

KHD Crawford, R Eguia, AS Dingens, AN Loes… - Viruses, 2020 - mdpi.com
SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing
antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated …

Acute SARS-CoV-2 infection impairs dendritic cell and T cell responses

R Zhou, KKW To, YC Wong, L Liu, B Zhou, X Li… - Immunity, 2020 - cell.com
The SARS-CoV-2 pandemic has resulted in millions of infections, yet the role of host
immune responses in early COVID-19 pathogenesis remains unclear. By investigating 17 …

Prospects for a safe COVID-19 vaccine

BF Haynes, L Corey, P Fernandes, PB Gilbert… - Science translational …, 2020 - science.org
Rapid development of an efficacious vaccine against the viral pathogen severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of the coronavirus disease …

Dynamics of neutralizing antibody titers in the months after severe acute respiratory syndrome coronavirus 2 infection

KHD Crawford, AS Dingens, R Eguia… - The Journal of …, 2021 - academic.oup.com
Most individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) develop neutralizing antibodies that target the viral spike protein. In this study, we …

[HTML][HTML] Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

B Korber, WM Fischer, S Gnanakaran, H Yoon… - BioRxiv, 2020 - biorxiv.org
We have developed an analysis pipeline to facilitate real-time mutation tracking in SARS-
CoV-2, focusing initially on the Spike (S) protein because it mediates infection of human …

Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?

G Milne, T Hames, C Scotton, N Gent… - The Lancet …, 2021 - thelancet.com
Many nations are pursuing the rollout of SARS-CoV-2 vaccines as an exit strategy from
unprecedented COVID-19-related restrictions. However, the success of this strategy relies …