Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

B Yang, F Zhang, F Cheng, L Ying, C Wang, K Shi… - Cell Death & …, 2020 - nature.com
Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such
patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous …

Trans-spinal electrical stimulation therapy for functional rehabilitation after spinal cord injury

MA Rahman, NS Tharu, SM Gustin, YP Zheng… - Journal of clinical …, 2022 - mdpi.com
Spinal cord injury (SCI) is one of the most debilitating injuries in the world. Complications
after SCI, such as respiratory issues, bowel/bladder incontinency, pressure ulcers …

Transcutaneous spinal cord stimulation restores hand and arm function after spinal cord injury

F Inanici, LN Brighton, S Samejima… - … on Neural Systems …, 2021 - ieeexplore.ieee.org
Paralysis of the upper extremity severely restricts independence and quality of life after
spinal cord injury. Regaining control of hand and arm movements is the highest treatment …

Cortical and subcortical effects of transcutaneous spinal cord stimulation in humans with tetraplegia

FD Benavides, HJ Jo, H Lundell… - Journal of …, 2020 - Soc Neuroscience
An increasing number of studies supports the view that transcutaneous electrical stimulation
of the spinal cord (TESS) promotes functional recovery in humans with spinal cord injury …

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

C Moritz, EC Field-Fote, C Tefertiller, I van Nes… - Nature medicine, 2024 - nature.com
Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions.
Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk …

Multisite transcutaneous spinal stimulation for walking and autonomic recovery in motor-incomplete tetraplegia: a single-subject design

S Samejima, CD Caskey, F Inanici… - Physical …, 2022 - academic.oup.com
Objective This study investigated the effect of cervical and lumbar transcutaneous spinal
cord stimulation (tSCS) combined with intensive training to improve walking and autonomic …

Combined transcutaneous spinal stimulation and locomotor training to improve walking function and reduce spasticity in subacute spinal cord injury: a randomized …

S Estes, A Zarkou, JM Hope, C Suri… - Journal of Clinical …, 2021 - mdpi.com
Locomotor training (LT) is intended to improve walking function and can also reduce
spasticity in motor-incomplete spinal cord injury (MISCI). Transcutaneous spinal stimulation …

Intrathecal and oral baclofen use in adults with spinal cord injury: A systematic review of efficacy in spasticity reduction, functional changes, dosing, and adverse …

N Dietz, S Wagers, SJ Harkema, JM D'Amico - Archives of Physical …, 2023 - Elsevier
Objective To examine the efficacy, dosing, and safety profiles of intrathecal and oral
baclofen in treating spasticity after spinal cord injury (SCI). Data Sources PubMed and …

Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord

US Hofstoetter, B Freundl, H Binder, K Minassian - PLoS One, 2019 - journals.plos.org
Posterior root-muscle (PRM) reflexes are short-latency spinal reflexes evoked by epidural or
transcutaneous spinal cord stimulation (SCS) in clinical and physiological studies. PRM …

Corticospinal motor circuit plasticity after spinal cord injury: harnessing neuroplasticity to improve functional outcomes

SF Kazim, CA Bowers, CD Cole, S Varela… - Molecular …, 2021 - Springer
Spinal cord injury (SCI) is a devastating condition that affects approximately 294,000 people
in the USA and several millions worldwide. The corticospinal motor circuitry plays a major …