Cellular pathways that repair chromosomal double-strand breaks (DSBs) have pivotal roles
in cell growth, development and cancer. These DSB repair pathways have been the target of …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

Polymerase theta (Pol θ, gene name Polq) is a widely conserved DNA polymerase that
mediates a microhomology-mediated, error-prone, double strand break (DSB) repair …

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in
mammalian cells, the relevant enzymatic pathway has not been identified. Here we define …

▪ Abstract DNA replication fidelity is a key determinant of genome stability and is central to
the evolution of species and to the origins of human diseases. Here we review our current …

DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) has been implicated in the
repair of chromosome breaks, but its cellular mechanism and role relative to canonical …

Mammalian polymerase theta (Polθ) is a multifunctional enzyme that promotes error-prone
DNA repair by alternative nonhomologous end joining (alt-NHEJ). Here we present structure …

The structural features that enable replicative DNA polymerases to synthesize DNA rapidly
and accurately also limit their ability to copy damaged DNA. Direct replication of DNA …

Polymerase theta (Polθ) acts in DNA replication and repair, and its inhibition is synthetic
lethal in BRCA1 and BRCA2-deficient tumor cells. Novobiocin (NVB) is a first-in-class …

Fanconi anaemia (FA) has recently become an attractive model to study breast cancer
susceptibility (BRCA) genes, as three FA genes, FANCD1, FANCN and FANCJ, are identical …