Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

Biosynthesis and regulation of diterpenoids in medicinal plants

REN Junze, WU Yu, ZHU Zhanpin, C Ruibing… - Chinese Journal of …, 2022 - Elsevier
Plant diterpenoids are widely distributed and abundant natural products with diverse
structures and functions in nature, which have been commonly used in pharmaceutical …

Functional Study and Efficient Catalytic Element Mining of CYP76AHs in Salvia Plants

Z Zhao, D Yang, J Guo, X Liu, Q Li, P Su, J Wang, Y Ma… - Molecules, 2023 - mdpi.com
Salvia is a large genus with hundreds of species used in traditional Chinese medicine.
Tanshinones are a highly representative class of exclusive compounds found in the Salvia …

CYP76BK1 orthologs catalyze furan and lactone ring formation in clerodane diterpenoids across the mint family

NJ Schlecht, ER Lanier, TB Andersen, J Brose… - The Plant …, 2024 - Wiley Online Library
The Lamiaceae (mint family) is the largest known source of furanoclerodanes, a subset of
clerodane diterpenoids with broad bioactivities including insect antifeedant properties. The …

A chromosome level reference genome of Diviner's sage (Salvia divinorum) provides insight into salvinorin A biosynthesis

SA Ford, RW Ness, M Kwon, DK Ro, MA Phillips - BMC Plant Biology, 2024 - Springer
Abstract Background Diviner's sage (Salvia divinorum; Lamiaceae) is the source of the
powerful hallucinogen salvinorin A (SalA). This neoclerodane diterpenoid is an agonist of …

DNA-compatible one-pot synthesis of multi-substituted dihydrofuran via pyridinium ylide-mediated cyclization

X Fang, X Ning, Y Li, G Zhang, X Fan… - Organic & Biomolecular …, 2025 - pubs.rsc.org
Synthesis of chemically diverse heterocyclic scaffolds in DNA-encoded libraries is highly
demanded. We herein reported a convenient one-pot multi-component on-DNA synthetic …

Identification of clerodane diterpene modifying cytochrome P450 (CYP728D26) in Salvia divinorum ‐ en route to psychotropic salvinorin A biosynthesis

I Ngo, R Kumar, L Li, SW Kim, M Kwon… - Physiologia …, 2024 - Wiley Online Library
Salvia divinorum is a hallucinogenic plant native to the Oaxaca in Mexico. The active
ingredient for psychotropic effects in this plant is salvinorin A, a potent and highly selective κ …

[HTML][HTML] The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae

H Li, S Wu, R Lin, Y Xiao, ALM Morotti, Y Wang… - Molecular Plant, 2023 - cell.com
The presence of anticancer clerodane diterpenoids is a chemotaxonomic marker for the
traditional Chinese medicinal plant Scutellaria barbata, although the molecular mechanisms …

Emily R. Lanier*, Nicholas J. Schlecht*, Trine B. Andersen, Bjoern R. Hamberger* These authors contributed equally to this work

NJS ERL - … IN CALLICARPA AMERICANA AND THE LAMIACEAE - search.proquest.com
The mint family (Lamiaceae) produces an abundance of specialized diterpenoid metabolites
which facilitate plant-environment interactions. Furanoclerodanes comprise a subset of …