The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …

SUMMARY Human herpesvirus 6 (HHV-6) is a betaherpesvirus that is closely related to
human cytomegalovirus. It was discovered in 1986, and HHV-6 literature has expanded …

Nucleoside analogues such as acyclovir and ganciclovir have been the mainstay of therapy
for alphaherpesviruses (herpes simplex virus (HSV) and varicella-zoster virus (VZV)) and …

Human cytomegalovirus (HCMV) infections are common and lead to lifelong infections. In
immunocompetent individuals, primary infections are mostly subclinical or they may be …

Mutations in the human CMV UL97 kinase gene are a major mechanism of viral resistance
to two anti‐CMV drugs, ganciclovir (GCV) and maribavir (MBV). GCV, the most widely used …

Human cytomegalovirus (HCMV) infection is a major cause of morbidity and mortality in
allogeneic hematopoietic stem cell transplant recipients. The significant clinical impact of …

This review discusses the management of resistant cytomegalovirus and prevention
strategies for fatal therapy failures. Five drugs, ganciclovir/valganciclovir, cidofovir, foscarnet …

Background Cytomegalovirus (CMV) seronegative recipients (R-) of kidney transplants (KT)
from seropositive donors (D+) are at higher risk for CMV replication and ganciclovir (GCV) …

Human cytomegalovirus (HCMV) is a pathogen that can be life-threatening in
immunocompromised individuals. Valganciclovir and its parent drug ganciclovir are …

Drug resistant strains of human cytomegalovirus (HCMV) in patients at risk may increasingly
develop into a problem in the clinical setting. Genotypic resistance testing is becoming the …