Harmonizing the neurobiology and treatment of obsessive-compulsive disorder

WK Goodman, EA Storch… - American Journal of …, 2021 - Am Psychiatric Assoc
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …

[HTML][HTML] Midfrontal theta activity in psychiatric illness: an index of cognitive vulnerabilities across disorders

G McLoughlin, M Gyurkovics, J Palmer, S Makeig - Biological Psychiatry, 2022 - Elsevier
There is an urgent need to identify the mechanisms that contribute to atypical thinking and
behavior associated with psychiatric illness. Behavioral and brain measures of cognitive …

Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls

M Biria, P Banca, MP Healy, E Keser, SJ Sawiak… - Nature …, 2023 - nature.com
There has been little analysis of neurochemical correlates of compulsive behaviour to
illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance …

Targeting the prefrontal-supplementary motor network in obsessive-compulsive disorder with intensified electrical stimulation in two dosages: a randomized …

J Alizadehgoradel, B Molaei, K Barzegar Jalali… - Translational …, 2024 - nature.com
Obsessive-compulsive disorder (OCD) is associated with a high disease burden, and
treatment options are limited. We used intensified electrical stimulation in two dosages to …

An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration

OA Van den Heuvel, PSW Boedhoe… - Human brain …, 2022 - Wiley Online Library
Neuroimaging has played an important part in advancing our understanding of the
neurobiology of obsessive–compulsive disorder (OCD). At the same time, neuroimaging …

Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive …

H Tomiyama, K Murayama, K Nemoto… - Human brain …, 2022 - Wiley Online Library
Recent evidence suggests that presupplementary motor area (pre‐SMA) and inferior frontal
gyrus (IFG) play an important role in response inhibition. However, no study has investigated …

Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis

X Li, J Wang - Brain imaging and behavior, 2021 - Springer
Background Abnormal neural activities during emotional processing have been found in
both adults and youths with major depressive disorder. However, findings were inconsistent …

[HTML][HTML] Real-world efficacy of deep TMS for obsessive-compulsive disorder: post-marketing data collected from twenty-two clinical sites

Y Roth, A Tendler, MK Arikan, R Vidrine, D Kent… - Journal of psychiatric …, 2021 - Elsevier
Background Deep transcranial magnetic stimulation (dTMS) with the H7-coil was FDA
cleared for obsessive-compulsive disorder (OCD) in August 2018 based on multicenter …

Evidence from “big data” for the default-mode hypothesis of ADHD: a mega-analysis of multiple large samples

LJ Norman, G Sudre, J Price, GG Shastri… - …, 2023 - nature.com
We sought to identify resting-state characteristics related to attention deficit/hyperactivity
disorder, both as a categorical diagnosis and as a trait feature, using large-scale samples …

Lower confidence and increased error sensitivity in OCD patients while learning under volatility

M Hoven, T Mulder, D Denys, RJ van Holst… - Translational …, 2024 - nature.com
A decoupling between confidence and action could relate to compulsive behaviour as seen
in obsessive-compulsive disorder (OCD). The link between confidence and action in OCD …