A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Humans lacking sclerostin display progressive bone overgrowth due to increased bone
formation. Although it is well established that sclerostin is an osteocyte-secreted bone …

Considered as one of the major epidemics of the 21st century, osteoporosis affects
approximately 200 million people globally, with significant worldwide impact on rates of …

Primary osteoporosis is an age-related disease characterized by an imbalance in bone
homeostasis. While the resorptive aspect of the disease has been studied intensely, less is …

Quantitative ultrasound of the heel captures heel bone properties that independently predict
fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be …

Developmental dysplasia of the hip (DDH) is one of the most common congenital skeletal
malformations; however, its etiology remains unclear. Here, we conducted whole-exome …

Publisher Summary Vitamin D is one of the major regulators of calcium homeostasis in the
body and is critically important for normal mineralization of bone. The active hormone, 1α, 25 …

OBJECTIVE: The objective of this study was to present a comprehensive model for the
pathogenesis of bisphosphonate-associated osteonecrosis of the jaw (BON). STUDY …

Exosomes, which mediate cell-to-cell communications and provide a novel insight into
information exchange, have drawn increasing attention in recent years. The homeostasis of …