The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …

While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors
are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors …

Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin
D manages protein turnover degrading misfolded and aggregated proteins and favors …

Despite mounting evidence suggesting the involvement of the immune system in regulating
brain function, the specific role of immune and inflammatory cells in neurodegenerative …

Mucins are functionally implicated in a range of human pathologies, including cystic fibrosis,
influenza, bacterial endocarditis, gut dysbiosis, and cancer. These observations have …

The tumor microenvironment (TME) significantly influences cancer evolution and therapeutic
efficacy. Targeting biofunctional molecules to the TME has long been appreciated as a …

The pancreas is a glandular organ with endocrine and exocrine functions necessary for the
maintenance of blood glucose homeostasis and secretion of digestive enzymes. Pancreatitis …

Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear
bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) …