Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, have
been reported to increase the malignant potency of cancer cells by secreting senescence …

The anti-tumor activities of some members of the chemokine family are often overcome by
the functions of many chemokines that are strongly and causatively linked with increased …

Cellular senescence is a form of proliferative arrest triggered in response to a wide variety of
stimuli and characterized by unique changes in cell morphology and function. Although …

It is acknowledged that cancer cells are able to undergo senescence in response to
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …

Background Demethyleneberberine (DMB) is a natural active component of medicinal plant
Cortex phellodendri chinensis with favorable bioactivity. However, the role of DMB in …

Chemokines, a subfamily of the cell cytokines, are low molecular weight proteins known to
induce chemotaxis in leukocytes in response to inflammatory and pathogenic signals. A …

Cellular senescence plays a paradoxical role in tumorigenesis through the expression of
diverse senescence-associated (SA) secretory phenotypes (SASPs). The heterogeneity of …

Cellular senescence is a stable cell cycle arrest state that can be triggered by a wide range
of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is …

Senescent tumor cells are nonproliferating tumor cells which are closely related to cancer
progression by secreting senescence-related molecules, called senescence-associated …

DNA damage response inhibitors (DDRi) may selectively enhance the inactivation of tumor
cells in combination with ionizing radiation (IR). The induction of senescence may be the key …