Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are
crucial for hearing and balance. In adult mammals, auditory hair cells are unable to …

Millions of people worldwide suffer from hearing and balance disorders caused by loss of
the sensory hair cells that convert sound vibrations and head movements into electrical …

The auditory organ of Corti is comprised of only two major cell types—the mechanosensory
hair cells and their associated supporting cells—both specified from a single pool of …

The adult mammalian inner ear lacks the capacity to divide or regenerate. Damage to inner
ear generally leads to permanent hearing loss in humans. Here, we present that …

Mammalian hair cells do not regenerate, and their loss is a major cause of deafness. We
recently identified leucine-rich repeat containing, G-protein-coupled receptor 5 (Lgr5) …

Mechanosensory hair cells of the mature mammalian organ of Corti do not regenerate;
consequently, loss of hair cells leads to permanent hearing loss. Although nonmammalian …

Inadequate nutrient intake leads to oxidative stress disrupting homeostasis, activating
signaling, and altering metabolism. Oxidative stress serves as a hallmark in developing …

Deafness caused by the terminal loss of inner ear hair cells is one of the most common
sensory diseases. However, nonmammalian animals (eg, birds, amphibians, and fish) …

Mechanosensitive hair cells (HCs) in the cochlear sensory epithelium are critical for sound
detection and transduction. Mammalian HCs in the cochlea undergo cytogenesis during …

Sensorineural hearing loss is the most common sensory deficit in humans. Despite the
global scale of the problem, only limited treatment options are available today. The …