Accumulating evidence suggests that the response of bacteria to antibiotics is significantly
affected by the presence of other interacting microbes. These interactions are not typically …

Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Antibiotics have transformed medicine, saving millions of lives since they were first used to
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …

Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The
past few decades have witnessed rapid progress in our understanding of the multiple factors …

Efforts to probe the role of the gut microbiota in disease would benefit from a system in which
patient-derived bacterial communities can be studied at scale. We addressed this by …

Competition between microbes is extremely common, with many investing in mechanisms to
harm other strains and species. Yet positive interactions between species have also been …

Chronic infections are frequently caused by polymicrobial biofilms. Importantly, these
infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to …

Biofilms are population of cells growing in a coordinated manner and exhibiting resistance
towards hostile environments. The infections associated with biofilms are difficult to control …

Chronic coinfections of Staphylococcus aureus and Pseudomonas aeruginosa frequently
fail to respond to antibiotic treatment, leading to significant patient morbidity and mortality …

History shows that the discovery of, and the resistance to, antibiotics go hand in hand. While
knowledge of resistance mechanisms, their impact and distribution is vast, over the years …