Obesity poses a severe threat to human health, including the increased prevalence of
hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and …

Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to
alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis …

Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through poorly defined mechanisms. Melatonin supplementation has been …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel housekeeper of
hepatic mitochondrial homeostasis outside the DNA repair process. In this study, DNA-PKcs …

A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …

Septic acute liver injury is one of the leading causes of fatalities in patients with sepsis. Toll-
like receptor 4 (TLR4) plays a vital role in response to lipopolysaccharide (LPS) challenge …

Autophagy is a catabolic process by which eukaryotic cells eliminate cytosolic materials
through vacuole-mediated sequestration and subsequent delivery to lysosomes for …

Type 2 diabetes mellitus (T2D) contributes to sustained inflammation and myopathic
changes in the heart although the precise interplay between the two remains largely …

Hepatic steatosis defined as lipid accumulation in hepatocytes is very frequently found in
adults and obese adolescents in the Western World. Etiologically, obesity and associated …

Mitochondrial DNA (mtDNA) released through protein oligomers, such as voltage-
dependent anion channel 1 (VDAC1), triggers innate immune activation and thus …