Intensive care unit (ICU) sedation practices have dramatically changed over the last 20
years [1–4]. Historically, patients were often deeply sedated to “let them rest”[4]. Strong …

Inhaled sedation with halogenated agents, such as isoflurane or sevoflurane, is now
feasible in intensive care unit (ICU) patients through dedicated vaporisers and scavenging …

Precision medicine is a growing field in critical care. Research increasingly demonstrated
pharmacogenomic variability to be an important determinant of analgesic and sedative drug …

Background: Volatile anesthetics were used as sedative agents in COVID-19 (Coronavirus
Disease 2019) invasively ventilated patients for their potentially beneficial pharmacological …

Inhaled sedation was recently approved in Europe as an alternative to intravenous sedative
drugs for intensive care unit (ICU) sedation. The aim of this narrative review was to …

Intensive care unit (ICU) sedation with sevoflurane is associated with nephrogenic diabetes
insipidus. Given that isoflurane is now licenced (in Europe) for ICU sedation and has …

Background Volatile anesthetics are used more commonly for sedation in the intensive-care-
unit (ICU). However, evidence for long-term use remains low. We therefore conducted a …

Background The COVID-19 pandemic has increased the number of patients in ICUs leading
to a worldwide shortage of the intravenous sedative agents obligating physicians to find …

Background Sedation of critically ill patients with inhaled anaesthetics may reduce lung
inflammation, time to extubation, and ICU length of stay compared with intravenous (iv) …

This review explores the complex interactions between sedation and invasive ventilation
and examines the potential of volatile anesthetics for lung-and diaphragm-protective …