Purpose To determine whether early goal-directed therapy (EGDT) reduces mortality
compared with other resuscitation strategies for patients presenting to the emergency …

In contrast to adults, cardiac arrest in infants and children does not usually result from a
primary cardiac cause. More often it is the terminal result of progressive respiratory failure or …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Rationale: Limited data exist about the international burden of severe sepsis in critically ill
children. Objectives: To characterize the global prevalence, therapies, and outcomes of …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

Objectives: The American College of Critical Care Medicine provided 2002 and 2007
guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the …

Background Severe infections kill more than 4· 5 million children every year. Population-
based data for severe infections in children requiring admission to intensive care units …

Background: The Institute of Medicine calls for the use of clinical guidelines and practice
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …

In patients with acute kidney injury (AKI), optimization of systemic haemodynamics is central
to the clinical management. However, considerable debate exists regarding the efficacy …

Abstract Background and purpose The Japanese Clinical Practice Guidelines for
Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of …