Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability

KA McGlynn, JL Petrick, WT London - Clinics in liver disease, 2015 - liver.theclinics.com
Primary liver cancer is the sixth most commonly occurring cancer in the world and the
second largest contributor to cancer mortality. 1 Globally, the most common histology …

[HTML][HTML] Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges

JA Malik, S Ahmed, B Jan, O Bender… - Biomedicine & …, 2022 - Elsevier
Breast cancer (BC) is mostly observed in women and is responsible for huge mortality in
women subjects globally. Due to the continued development of drug resistance and other …

Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response

LY Yang, Q Luo, L Lu, WW Zhu, HT Sun, R Wei… - Journal of hematology & …, 2020 - Springer
Background The propensity of the activated neutrophils to form extracellular traps (NETs) is
demonstrated in multiple inflammatory conditions. In this study, we investigated the roles of …

Association of aspirin with hepatocellular carcinoma and liver-related mortality

TG Simon, AS Duberg, S Aleman… - … England Journal of …, 2020 - Mass Medical Soc
Background More information is needed about the long-term effects of low-dose aspirin (≤
160 mg) on incident hepatocellular carcinoma, liver-related mortality, and gastrointestinal …

Association between aspirin use and risk of hepatocellular carcinoma

TG Simon, Y Ma, JF Ludvigsson, DQ Chong… - JAMA …, 2018 - jamanetwork.com
Importance Prospective data on the risk of hepatocellular carcinoma (HCC) according to
dose and duration of aspirin therapy are limited. Objective To examine the potential benefits …

PTEN tumor-suppressor: the dam of stemness in cancer

F Luongo, F Colonna, F Calapà, S Vitale, ME Fiori… - Cancers, 2019 - mdpi.com
PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor‐associated macrophages

D Capece, M Fischietti, D Verzella… - BioMed research …, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human cancers
worldwide. HCC is an example of inflammation‐related cancer and represents a paradigm …

MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity

H Su, JR Yang, T Xu, J Huang, L Xu, Y Yuan… - Cancer research, 2009 - AACR
Although aberrant microRNA (miRNA) expressions have been observed in different types of
cancer, their pathophysiologic role and their relevance to tumorigenesis are still largely …

Inflammation and liver cancer: new molecular links

C Berasain, J Castillo, MJ Perugorria… - Annals of the New …, 2009 - Wiley Online Library
A connection between inflammation and cancer has been long suspected. Epidemiological
studies have established that many tumors occur in association with chronic infectious …

Obesity and hepatocellular carcinoma

SH Caldwell, DM Crespo, HS Kang, AMS Al-Osaimi - Gastroenterology, 2004 - Elsevier
Epidemiological studies have shown that obesity is a risk factor for hepatocellular
carcinoma. Similar studies further indicate that diabetes is also a major risk factor. Both …