Therapeutic potential of ectopic olfactory and taste receptors

SJ Lee, I Depoortere, H Hatt - Nature Reviews Drug Discovery, 2019 - nature.com
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …

[HTML][HTML] Human olfactory receptors: novel cellular functions outside of the nose

D Maßberg, H Hatt - Physiological reviews, 2018 - journals.physiology.org
Olfactory receptors (ORs) are not exclusively expressed in the olfactory sensory neurons;
they are also observed outside of the olfactory system in all other human tissues tested to …

[HTML][HTML] Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer

P Zhang, M Yang, Y Zhang, S Xiao, X Lai, A Tan, S Du… - Cell reports, 2019 - cell.com
Intestinal-type gastric cancer is preceded by premalignant lesions, including chronic
atrophic gastritis and intestinal metaplasia. In this study, we constructed a single-cell atlas …

High-resolution mRNA and secretome atlas of human enteroendocrine cells

J Beumer, J Puschhof, J Bauzá-Martinez… - Cell, 2020 - cell.com
Enteroendocrine cells (EECs) sense intestinal content and release hormones to regulate
gastrointestinal activity, systemic metabolism, and food intake. Little is known about the …

Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes

A Malki, J Fiedler, K Fricke, I Ballweg… - Journal of Leucocyte …, 2015 - academic.oup.com
Our cellular immune system has to cope constantly with foodborne substances that enter the
bloodstream postprandially. Here, they may activate leukocytes via specific but yet mostly …

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor

N Jovancevic, A Dendorfer, M Matzkies… - Basic research in …, 2017 - Springer
Several studies have demonstrated the expression of odorant receptors (OR) in various
human tissues and their involvement in different physiological and pathophysiological …

[HTML][HTML] Odorant receptors in cancer

C Chung, HJ Cho, CE Lee, JH Koo - BMB reports, 2022 - ncbi.nlm.nih.gov
Odorant receptors (ORs), the largest subfamily of G protein-coupled receptors, detect
odorants in the nose. In addition, ORs were recently shown to be expressed in many …

Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation

G Sanz, I Leray, A Dewaele, J Sobilo, S Lerondel… - PloS one, 2014 - journals.plos.org
Olfactory receptors (ORs) are expressed in the olfactory epithelium, where they detect
odorants, but also in other tissues with additional functions. Some ORs are even …

Beyond the flavour: the potential druggability of chemosensory G protein-coupled receptors

A Di Pizio, M Behrens, D Krautwurst - International journal of molecular …, 2019 - mdpi.com
G protein-coupled receptors (GPCRs) belong to the largest class of drug targets.
Approximately half of the members of the human GPCR superfamily are chemosensory …

Olfactory receptors as biomarkers in human breast carcinoma tissues

L Weber, D Maßberg, C Becker, J Altmüller… - Frontiers in …, 2018 - frontiersin.org
Olfactory receptors (ORs) are known to be expressed in a variety of human tissues and act
on different physiological processes, such as cell migration, proliferation, or secretion and …