Advances in nucleic acid-targeted therapies for cardiovascular disease prevention
U Makhmudova, E Steinhagen-Thiessen… - Cardiovascular …, 2024 - academic.oup.com
Nucleic acid-based therapies are being rapidly developed for prevention and management
of cardiovascular diseases (CVD). Remarkable advancements have been achieved in the …
of cardiovascular diseases (CVD). Remarkable advancements have been achieved in the …
SLKB: synthetic lethality knowledge base
Emerging CRISPR–Cas9 technology permits synthetic lethality (SL) screening of large
number of gene pairs from gene combination double knockout (CDKO) experiments …
number of gene pairs from gene combination double knockout (CDKO) experiments …
Exploring retinal degenerative diseases through CRISPR-based screening
The CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-
associated protein9) system has emerged as a powerful genetic tool, gaining global …
associated protein9) system has emerged as a powerful genetic tool, gaining global …
Synthetic lethal connectivity and graph transformer improve synthetic lethality prediction
Synthetic lethality (SL) has shown great promise for the discovery of novel targets in cancer.
CRISPR double-knockout (CDKO) technologies can only screen several hundred genes …
CRISPR double-knockout (CDKO) technologies can only screen several hundred genes …
Utilizing Computer Vision for Continuous Monitoring of Vaccine Side Effects in Experimental Mice
The demand for improved efficiency and accuracy in vaccine safety assessments is
increasing. Here, we explore the application of computer vision technologies to automate …
increasing. Here, we explore the application of computer vision technologies to automate …
Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs
Emerging immunotherapies such as immune checkpoint blockade (ICB) and chimeric
antigen receptor T-cell (CAR-T) therapy have revolutionized cancer treatment and have …
antigen receptor T-cell (CAR-T) therapy have revolutionized cancer treatment and have …
Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome Screening
Triple-negative breast cancer (TNBC) represents 15-20% of cases but disproportionately
contributes to 35% of breast cancer deaths. Chemotherapy resistance remains a significant …
contributes to 35% of breast cancer deaths. Chemotherapy resistance remains a significant …
CRISPR Double Knockout Library Reveals Synthetic Lethal Gene Pairs in Triple-Negative Breast Cancer
Synthetic lethality, a genetic interaction involving two or more genes whose combined loss
results in cell death, has emerged as a promising strategy for targeted cancer therapy. By …
results in cell death, has emerged as a promising strategy for targeted cancer therapy. By …
pgMAP: a pipeline to enable guide RNA read mapping from dual-targeting CRISPR screens
We developed pgMAP, an analysis pipeline to map gRNA sequencing reads from dual-
targeting CRISPR screens. pgMAP output includes a dual gRNA read counts table and …
targeting CRISPR screens. pgMAP output includes a dual gRNA read counts table and …
Identifying Representative Cell Line Models for TNBC Chemotherapy Drug Resistance via Systems Biology and Bioinformatics
S Shao, L Li - bioRxiv, 2024 - biorxiv.org
Cancer cell lines, derived from tumors, have become essential tools in life science research
and are commonly employed as experimental model systems in cancer research. However …
and are commonly employed as experimental model systems in cancer research. However …