The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
pathway is activated in the majority of human cancers. This pathway is known to play a key …

Overexpression of human epidermal growth factor receptor type 2 (HER2) in breast cancer
is associated with decreased overall survival. Trastuzumab, a humanized monoclonal …

ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …

The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that
constitutes one of four members of the erbB family of tyrosine kinase receptors. Binding of …

The ErbB2-targeting antibody, trastuzumab (Herceptin), has remarkable therapeutic efficacy
in certain patients with ErbB2-overexpressing tumors. The overall trastuzumab response …

Cancer chemotherapy has been one of the major medical advances in the last few decades.
However, the drugs used for this therapy have a narrow therapeutic index, and often the …

Non-receptor and receptor tyrosine kinases, such as Src and EGF receptor (EGFR), are
major inducers of vascular endothelial growth factor (VEGF), one of the most potent …

HER2 is a transmembrane oncoprotein encoded by the HER2/neu gene and is
overexpressed in approximately 20 to 25% of invasive breast cancers. It can be …