Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …

Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Endogenous mechanisms that act in the resolution of acute inflammation are essential for
host defense and the return to homeostasis. Resolvin D1 (RvD1), biosynthesized during …

Background—Cystathionine γ-lyase (CSE) produces hydrogen sulfide (H2S) in the
cardiovascular system. The deficiency of CSE in mice leads to a decreased endogenous …

The polarization of adipose tissue-resident macrophages toward the alternatively activated,
anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the …

Abstract The pathophysiology of Non-Alcoholic Steatohepatitis (NASH) encompasses a
complex set of intra-and extrahepatic driving mechanisms, involving numerous metabolic …

Obesity, is an increasingly global public health problem associated complications. However,
the proven anti-obesity agents are inefficient with adverse side effects; hence attention is …

Cells are richly equipped with nuclear receptors, which act as ligand-regulated transcription
factors. Peroxisome proliferator activated receptors (PPARs), members of the nuclear …