Voltage-gated potassium channels as therapeutic targets

H Wulff, NA Castle, LA Pardo - Nature reviews Drug discovery, 2009 - nature.com
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Olfaction under metabolic influences

B Palouzier-Paulignan, MC Lacroix, P Aimé… - Chemical …, 2012 - academic.oup.com
Recently published work and emerging research efforts have suggested that the olfactory
system is intimately linked with the endocrine systems that regulate or modify energy …

Kv1. 3 modulates neuroinflammation and neurodegeneration in Parkinson's disease

S Sarkar, HM Nguyen, E Malovic, J Luo… - The Journal of …, 2020 - Am Soc Clin Investig
Characterization of the key cellular targets contributing to sustained microglial activation in
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …

The endocannabinoid system controls food intake via olfactory processes

E Soria-Gómez, L Bellocchio, L Reguero… - Nature …, 2014 - nature.com
Hunger arouses sensory perception, eventually leading to an increase in food intake, but the
underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) …

Food odor perception promotes systemic lipid utilization

H Tsuneki, M Sugiyama, T Ito, K Sato, H Matsuda… - Nature …, 2022 - nature.com
Food cues during fasting elicit Pavlovian conditioning to adapt for anticipated food intake.
However, whether the olfactory system is involved in metabolic adaptations remains elusive …

Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors

DR Marks, K Tucker, MA Cavallin, TG Mast… - Journal of …, 2009 - Soc Neuroscience
The role of insulin pathways in olfaction is of significant interest with the widespread
pathology of diabetes mellitus and its associated metabolic and neuronal comorbidities. The …

[HTML][HTML] Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series

O Honmou, T Yamashita, T Morita, T Oshigiri… - Clinical Neurology and …, 2021 - Elsevier
Background Although spinal cord injury (SCI) is a major cause of disability, current
therapeutic options remain limited. Recent progress in cellular therapy with mesenchymal …

K+ Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases

H Wulff, BS Zhorov - Chemical reviews, 2008 - ACS Publications
Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning

N Thiebaud, MC Johnson, JL Butler… - Journal of …, 2014 - Soc Neuroscience
Currently, 65% of Americans are overweight, which leads to well-supported cardiovascular
and cognitive declines. Little, however, is known concerning obesity's impact on sensory …

Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia

JM Argilés, S Busquets, A Felipe… - The international journal …, 2005 - Elsevier
The aim of the present review is to summarize and evaluate the different mechanisms and
catabolic mediators involved in cancer cachexia and ageing sarcopenia since they may …