Diabetic nephropathy (DN) is reported as one of the most serious microvascular diabetic
complications and the trigger of end-stage renal disease (ESRD), underscoring the concern …

Methotrexate (MTX) is a cytotoxic chemotherapeutic agent used for treatment of several
cancers. Nephrotoxicity, an adverse side effect of high-dose MTX, is attributed to abnormal …

Cysteinyl leukotrienes released by mast cells trigger the symptoms of asthma, including
bronchoconstriction and vasoconstriction. Therefore, effective leukotriene inhibitors were …

Male reproductive dysfunction is one of the overlooked findings of diabetes mellitus (DM)
that deserves greater scientific attention. This study is designed to explore the therapeutic …

Background: The therapeutic use of the antineoplastic drug cisplatin (DDP) in the elderly is
limited by its nephrotoxic effects. The aim of this study was to examine the effect of short-term …

Methods: The authors conducted a scoping review using PubMed, Scopus, and Web of
Science databases to identify relevant studies investigating the impact of montelukast on …

Montelukast, a leukotriene receptor antagonist, is used commercially as a maintenance
treatment for asthma and to relieve allergic symptoms. In this study, we evaluated the …

Objective The current study investigated for the first time the possible beneficial effect of
zileuton, a selective 5-lipoxygenase inhibitor (5-LOX), against cisplatin-induced acute renal …

Abstract The enzyme 5-lipoxygenase (5-LO) converts arachidonic acid to leukotrienes,
which mediate inflammation. The enzyme is known to contribute to organ fibrosis, but how it …

Purpose In this study, we evaluated the renal protective effects of montelukast (MLK) against
ionizing radiation (IR) induced nephrotoxicity in mice. Materials and Methods …