Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Introduction: MicroRNAs (miRNAs), which are evolutionarily conserved, and endogenous
non-coding RNAs, participate in the post-transcriptional regulation of eukaryotic genes. The …

Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …

Accurate and individualized prediction of response to therapies is central to precision
medicine. However, because of the generally complex and multifaceted nature of clinical …

Epilepsy is a common and serious neurological disorder characterised by recurrent
spontaneous seizures. Frontline pharmacotherapy includes small-molecule antiseizure …

Background There are no blood-based molecular biomarkers of temporal lobe epilepsy
(TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong …

Epilepsy is a common and devastating neurological disorder characterized by recurrent and
unprovoked spontaneous seizures. One leading hypothesis for the development and …

There is a need for diagnostic biomarkers of epilepsy and status epilepticus to support
clinical examination, electroencephalography and neuroimaging. Extracellular microRNAs …

Epigenetic modifications are emerging as major players in the pathogenesis of
neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone …

Neurological diseases including Alzheimer's, Huntington's disease, Parkinson's disease,
Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are …