Imaging synaptic density: the next holy grail of neuroscience?

ME Serrano, E Kim, MM Petrinovic… - Frontiers in …, 2022 - frontiersin.org
The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

Detecting early cognitive decline in alzheimer's disease with brain synaptic structural and functional evaluation

S Ribarič - Biomedicines, 2023 - mdpi.com
Early cognitive decline in patients with Alzheimer's (AD) is associated with quantifiable
structural and functional connectivity changes in the brain. AD dysregulation of Aβ and tau …

Fluorescence Microscopy: a statistics-optics perspective

M Fazel, KS Grussmayer, B Ferdman, A Radenovic… - Reviews of Modern …, 2024 - APS
Fundamental properties of light unavoidably impose features on images collected using
fluorescence microscopes. Accounting for these features is often critical in quantitatively …

Comparison of corneal tomography using a novel swept-source optical coherence tomographer and rotating Scheimpflug system in normal and keratoconus eyes …

R Herber, J Lenk, LE Pillunat, F Raiskup - Eye and Vision, 2022 - Springer
Background To determine the repeatability and agreement using corneal tomography of a
swept-source optical coherence tomographer (SS-OCT) compared to a rotating Scheimpflug …

The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy

B Johansson, S Oasa, A Muntsant Soria, A Tiiman… - Cell & Bioscience, 2023 - Springer
Background Standard neuropathologic analysis of Alzheimer's brain relies on traditional
fluorescence microscopy, which suffers from limited spatial resolution due to light diffraction …

Keratoconus diagnosis: from fundamentals to artificial intelligence: a systematic narrative review

S Niazi, M Jiménez-García, O Findl, Z Gatzioufas… - Diagnostics, 2023 - mdpi.com
The remarkable recent advances in managing keratoconus, the most common corneal
ectasia, encouraged researchers to conduct further studies on the disease. Despite the …

[HTML][HTML] Reliability of optical coherence tomography angiography retinal blood flow analyses

EF Courtie, A Gilani, N Capewell… - … Vision Science & …, 2023 - jov.arvojournals.org
Purpose: Investigate the association between the optical coherence tomography
angiography (OCTA) metrics derived from different analysis programs to understand the …

Deep learning enabled hemorrhage detection in retina with DPFE and splat segmentation in fundus images

LG Atlas, KP Arjun, KS Kumar, RK Dhanaraj… - … Signal Processing and …, 2024 - Elsevier
The range of diabetics, hypertension, occlusions in vascular are rapidly increasing in the
modern era. Adversarial effects of these diseases are the organ damage which is increasing …

Challenges facing quantitative large-scale optical super-resolution, and some simple solutions

TM Dankovich, SO Rizzoli - Iscience, 2021 - cell.com
Optical super-resolution microscopy (SRM) has enabled biologists to visualize cellular
structures with near-molecular resolution, giving unprecedented access to details about the …

Comparison of different metrics for the identification of vascular changes in diabetic retinopathy using OCTA

L Mendes, IP Marques, J Cunha-Vaz - Frontiers in Neuroscience, 2021 - frontiersin.org
Retinal vessel metrics identifying microvascular changes such as vessel closure (VC) have
shown potential clinical value by identifying eyes with diabetic retinopathy (DR) at different …