Approaching genetics through the MHC lens: tools and methods for HLA research
V Douillard, EC Castelli, SJ Mack, JA Hollenbach… - Frontiers in …, 2021 - frontiersin.org
The current SARS-CoV-2 pandemic era launched an immediate and broad response of the
research community with studies both about the virus and host genetics. Research in …
research community with studies both about the virus and host genetics. Research in …
Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil
As whole-genome sequencing (WGS) becomes the gold standard tool for studying
population genomics and medical applications, data on diverse non-European and admixed …
population genomics and medical applications, data on diverse non-European and admixed …
MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals
Despite the high number of individuals infected by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) symptoms …
coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) symptoms …
HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia
Immune aplastic anemia (AA) features somatic loss of HLA class I allele expression on bone
marrow cells, consistent with a mechanism of escape from T-cell–mediated destruction of …
marrow cells, consistent with a mechanism of escape from T-cell–mediated destruction of …
Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression
Human leukocyte antigen (HLA) class I and II loci are essential elements of innate and
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …
How HLA diversity is apportioned: influence of selection and relevance to transplantation
In his 1972 paper 'The apportionment of human diversity', Lewontin showed that, when
averaged over loci, genetic diversity is predominantly attributable to differences among …
averaged over loci, genetic diversity is predominantly attributable to differences among …
MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil
Background Although aging correlates with a worse prognosis for Covid-19, super elderly
still unvaccinated individuals presenting mild or no symptoms have been reported …
still unvaccinated individuals presenting mild or no symptoms have been reported …
HLA-G genetic diversity and evolutive aspects in worldwide populations
HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents
substantial nucleotide variability in its regulatory regions. However, it encodes a limited …
substantial nucleotide variability in its regulatory regions. However, it encodes a limited …
The oldest unvaccinated Covid-19 survivors in South America
Background Although older adults are at a high risk of severe or critical Covid-19, there are
many cases of unvaccinated centenarians who had a silent infection or recovered from mild …
many cases of unvaccinated centenarians who had a silent infection or recovered from mild …
Contribution of unfixed transposable element insertions to human regulatory variation
C Goubert, NA Zevallos… - … Transactions of the …, 2020 - royalsocietypublishing.org
Thousands of unfixed transposable element (TE) insertions segregate in the human
population, but little is known about their impact on genome function. Recently, a few studies …
population, but little is known about their impact on genome function. Recently, a few studies …