Fibrin plays an essential role in hemostasis as both the primary product of the coagulation
cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly …

▪ Abstract Recent studies showing that detergent-resistant membrane fragments can be
isolated from cells suggest that biological membranes are not always in a liquid-crystalline …

Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms
ranging from gene amplification to post-transcriptional modification. Their localization within …

The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are
known primarily for their ability to transport molecules across endothelial cells, but modern …

The molecular mechanisms that finely co‐ordinate fibrin formation and fibrinolysis are now
well defined. The structure and function of all major fibrinolytic proteins, which include serine …

The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …

Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

The clearest function of membrane lipids is to form amphipathic bilayers that surround cells
and organelles and block leakage of hydrophilic compounds while housing membrane …

The tumor stroma in human cancers significantly limits the delivery of therapeutic agents into
cancer cells. To develop an effective therapeutic approach overcoming the physical barrier …

Investigators have been studying the expression and activity of proteases in the final steps of
tumor progression, invasion and metastasis, for the past 30 years. Recent studies, however …