Cancer in the broader sense refers to more than 277 different types of cancer disease.
Scientists have identified different stage of cancers, indicating that several gene mutations …

Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …

Vascular pericytes, an important cellular component in the tumor microenvironment, are
often associated with tumor vasculatures, and their functions in cancer invasion and …

c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …

This review—the first in a series concerning the biology of cancer—is a comprehensive
survey of oncogenes, tumor-suppressor genes, and microRNA genes in cancer cells. Work …

ContextMore persons in the United States die from non–small cell lung cancer (NSCLC)
than from breast, colorectal, and prostate cancer combined. In preclinical testing, oral …

One challenging aspect in the clinical development of molecularly targeted therapies, which
represent a new and promising approach to treating cancers, has been the identification of a …

In the early 1980s, it became apparent that the work of pioneers such as Robert Weinberg,
Mariano Barbacid and many others in identifying cancer-causing genes in humans was …

BACKGROUND Recent breakthroughs regarding gastrointestinal stromal tumors (GIST) and
their pathogenesis have redefined diagnostic criteria and have led to the development of …

Sunitinib (SU011248) is an oral small molecular tyrosine kinase inhibitor that exhibits potent
antiangiogenic and antitumor activity. Tyrosine kinase inhibitors such as SU6668 and …