Open questions in the study of de novo genes: what, how and why

A McLysaght, LD Hurst - Nature Reviews Genetics, 2016 - nature.com
The study of de novo protein-coding genes is maturing from the ad hoc reporting of
individual cases to the systematic analysis of extensive genomic data from several species …

Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus

MG Lawrence, J Lai, JA Clements - Endocrine reviews, 2010 - academic.oup.com
The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

miRDeep*: an integrated application tool for miRNA identification from RNA sequencing data

J An, J Lai, ML Lehman, CC Nelson - Nucleic acids research, 2013 - academic.oup.com
Abstract miRDeep and its varieties are widely used to quantify known and novel micro RNA
(miRNA) from small RNA sequencing (RNAseq). This article describes miRDeep*, our …

Involvement of kallikrein‐related peptidases in normal and pathologic processes

ACB Stefanini, BR da Cunha, T Henrique… - Disease …, 2015 - Wiley Online Library
Human kallikrein‐related peptidases (KLKs) are a subgroup of serine proteases that
participate in proteolytic pathways and control protein levels in normal physiology as well as …

[HTML][HTML] Comprehensively evaluating cis-regulatory variation in the human prostate transcriptome by using gene-level allele-specific expression

NB Larson, S McDonnell, AJ French, Z Fogarty… - The American Journal of …, 2015 - cell.com
The identification of cis-acting regulatory variation in primary tissues has the potential to
elucidate the genetic basis of complex traits and further our understanding of transcriptomic …

Kallikreins are involved in an miRNA network that contributes to prostate cancer progression

S Samaan, Z Lichner, Q Ding, C Saleh… - Biological …, 2014 - degruyter.com
MicroRNAs (miRNAs) are short RNA nucleotides that negatively regulate their target genes.
They are differentially expressed in prostate cancer. Kallikreins are genes that encode …

[HTML][HTML] Pseudogene associated recurrent gene fusion in prostate cancer

BVSK Chakravarthi, P Dedigama-Arachchige… - Neoplasia, 2019 - Elsevier
We present the functional characterization of a pseudogene associated recurrent gene
fusion in prostate cancer. The fusion gene KLK4-KLKP1 is formed by the fusion of the …

The network structure of hematopoietic cancers

AK Nakamura-García, J Espinal-Enríquez - Scientific Reports, 2023 - nature.com
Hematopoietic cancers (HCs) are a heterogeneous group of malignancies that affect blood,
bone marrow and lymphatic system. Here, by analyzing 1960 RNA-Seq samples from three …

Functional characterization of BC039389-GATM and KLK4-KRSP1 chimeric read-through transcripts which are up-regulated in renal cell cancer

D Pflueger, C Mittmann, S Dehler, MA Rubin, H Moch… - BMC genomics, 2015 - Springer
Abstract Background Chimeric read-through RNAs are transcripts originating from two
directly adjacent genes (< 10 kb) on the same DNA strand. Although they are found in next …

Genetic Association of the KLK4 Locus with Risk of Prostate Cancer

F Lose, S Srinivasan, T O'Mara, L Marquart… - 2012 - journals.plos.org
The Kallikrein-related peptidase, KLK4, has been shown to be significantly overexpressed in
prostate tumours in numerous studies and is suggested to be a potential biomarker for …