Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

In this narrative review, a theoretical framework on the crosstalk between physical exercise
and blood-brain barrier (BBB) permeability is presented. We discuss the influence of …

Age is characterized by chronic inflammation, leading to synaptic dysfunction and dementia
because the clearance of protein waste is reduced. The clearance of proteins depends …

Diabetes mellitus (DM) is one of the most common diseases in the world. Among its effects
are an increase in the risk of cognitive impairment, including Alzheimer's disease, and blood …

Immunosenescence contribute to increase the blood-brain barrier (BBB) permeability,
leading cognitive impairment and neurodegeneration. Thus, we investigated the anti …

Aerobic exercise has emerged as a promising intervention for mild cognitive impairment
(MCI), a precursor to dementia. The therapeutic benefits of aerobic exercise are …

Schizophrenia (SZ) is a severe mental disorder with unknown etiology and elusive
neuropathological and neurobiological features have been a focus of many theoretical …

Metabolic diseases including obesity, insulin resistance and diabetes have profound effects
on cerebral circulation. These diseases not only affect the architecture of cerebral blood …

The blood-brain barrier (BBB) is a complex multicellular structure acting as selective barrier
controlling the transport of substances between these compartments. Accumulating …

Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey
showed that AD genome-wide association study (GWAS) genes (localized in bone marrow …