Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

Fast synaptic communication in the brain requires synchronous vesicle fusion that is evoked
by action potential-induced Ca2+ influx. However, synaptic terminals also release …

Synaptic vesicle docking, priming, and fusion at active zones are orchestrated by a complex
molecular machinery. We employed hippocampal organotypic slice cultures from mice …

The two universally required components of the intracellular membrane fusion machinery,
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …

Persistent changes in tree mortality rates can alter forest structure, composition, and
ecosystem services such as carbon sequestration. Our analyses of longitudinal data from …

Most neuronal communication relies upon the synchronous release of neurotransmitters,
which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a …

Extensive research has yielded crucial insights into the mechanism of neurotransmitter
release, and working models for the functions of key proteins involved in release. The …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon
Ca 2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes …