Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
Aging and rejuvenation of neural stem cells and their niches
Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …
declining cognitive function and enhanced risk of brain diseases, including cancer and …
Traumatic brain injury: current treatment strategies and future endeavors
Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of
consciousness to an unrelenting comatose state and death. In the most severe form of TBI …
consciousness to an unrelenting comatose state and death. In the most severe form of TBI …
Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain
Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in
the neurovascular unit between endothelial cells, astrocytes and neurons. This position …
the neurovascular unit between endothelial cells, astrocytes and neurons. This position …
Microglia play an active role in obesity-associated cognitive decline
Obesity affects> 600 million people worldwide, a staggering number that appears to be on
the rise. One of the lesser known consequences of obesity is its deleterious effects on …
the rise. One of the lesser known consequences of obesity is its deleterious effects on …
No-reflow phenomenon in the heart and brain
The no-reflow phenomenon refers to the observation that when an organ is made ischemic
by occlusion of a large artery supplying it, restoration of patency in that artery does not …
by occlusion of a large artery supplying it, restoration of patency in that artery does not …
Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression
MM Al-Dabet, K Shahzad, A Elwakiel, A Sulaj… - Nature …, 2022 - nature.com
A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific
therapies. Here we show that glucose-mediated changes in gene expression largely persist …
therapies. Here we show that glucose-mediated changes in gene expression largely persist …
Final results of the RHAPSODY trial: a multi‐center, phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A‐APC, a …
Objective Agonism of protease‐activated receptor (PAR) 1 by activated protein C (APC)
provides neuro‐and vasculoprotection in experimental neuroinjury models. The pleiotropic …
provides neuro‐and vasculoprotection in experimental neuroinjury models. The pleiotropic …
Activated protein C, protease activated receptor 1, and neuroprotection
JH Griffin, BV Zlokovic… - Blood, The Journal of the …, 2018 - ashpublications.org
Protein C is a plasma serine protease zymogen whose active form, activated protein C
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …
Silk fibroin: An ancient material for repairing the injured nervous system
M Yonesi, M Garcia-Nieto, GV Guinea, F Panetsos… - Pharmaceutics, 2021 - mdpi.com
Silk refers to a family of natural fibers spun by several species of invertebrates such as
spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has …
spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has …