Matrix metalloproteinases shape the tumor microenvironment in cancer progression

S Niland, AX Riscanevo, JA Eble - International journal of molecular …, 2021 - mdpi.com
Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Biochemical and biological attributes of matrix metalloproteinases

N Cui, M Hu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …

Matrix metalloproteinases, vascular remodeling, and vascular disease

X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

How matrix metalloproteinases regulate cell behavior

MD Sternlicht, Z Werb - Annual review of cell and …, 2001 - annualreviews.org
▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants

JM Cook-Mills, ME Marchese… - Antioxidants & redox …, 2011 - liebertpub.com
The endothelium is immunoregulatory in that inhibiting the function of vascular adhesion
molecules blocks leukocyte recruitment and thus tissue inflammation. The function of …

Role of integrins in cell invasion and migration

JD Hood, DA Cheresh - Nature Reviews Cancer, 2002 - nature.com
As cancer cells undergo metastasis—invasion and migration of a new tissue—they
penetrate and attach to the target tissue's basal matrix. This allows the cancer cell to pull …

Strategies for MMP inhibition in cancer: innovations for the post-trial era

CM Overall, C López-Otín - Nature Reviews Cancer, 2002 - nature.com
For more than two decades, the view that tumour-associated matrix metalloproteinases
(MMPs) were required for peritumour tissue degradation and metastasis dominated the drive …

Matrix metalloproteinases in tumor invasion and metastasis

I Stamenkovic - Seminars in cancer biology, 2000 - Elsevier
Extensive work on the mechanisms of tumor invasion and metastasis has identified matrix
metalloproteinases (MMPs) as key players in the events that underlie tumor dissemination …

Matrix metalloproteinases in wound repair

L Ravanti, VM Kähäri - International journal of …, 2000 - spandidos-publications.com
Wound repair is initiated with the aggregation of platelets, formation of a fibrin clot, and
release of growth factors from the activated coagulation pathways, injured cells, platelets …

Matrix metalloproteinase inhibition by green tea catechins

M Demeule, M Brossard, M Pagé, D Gingras… - … et Biophysica Acta (BBA …, 2000 - Elsevier
We have investigated the effects of different biologically active components from natural
products, including green tea polyphenols (GTP), resveratrol, genistein and organosulfur …