The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Glucose and related sugars repress the transcription of genes encoding enzymes required
for the utilization of alternative carbon sources; some of these genes are also repressed by …

During gene transcription, RNA polymerase II (RNAPII) traverses nucleosomes in chromatin,
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …

Particular chromatin modifications are associated with different states of gene transcription,
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …

Over the past years, a large number of histone posttranslational modifications have been
described, some of which function to attain a repressed chromatin structure, while others …

We report here the identification of a gene associated with the hyperparathyroidism–jaw
tumor (HPT–JT) syndrome. A single locus associated with HPT–JT (HRPT2) was previously …

The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP
II) have identified this stage as a dynamic and highly regulated step of the transcription …

Transcription initiation by RNA polymerase II (RNA pol II) requires interaction between cis-
acting promoter elements and trans-acting factors. The eukaryotic promoter consists of core …

To physically characterize the web of interactions connecting the Saccharomyces cerevisiae
proteins suspected to be RNA polymerase II (RNAPII) elongation factors, subunits of …