Natural proteins are often only slightly more stable in the native state than the denatured
state, and an increase in environmental temperature can easily shift the balance toward …

Natural products, a chemically and structurally diverse class of molecules, possess a wide
spectrum of biological activities, have been used therapeutically for millennia, and have …

The cytochrome P450 family 1 enzymes (CYP1s) are a diverse family of hemoprotein
monooxygenases, which metabolize many xenobiotics including numerous environmental …

Selective, one‐step C− H activation of fatty acids from biomass is an attractive concept in
sustainable chemistry. Biocatalysis has shown promise for generating high‐value hydroxy …

Employing ancestral sequence reconstruction and consensus sequence analysis, the
thermostability of a novel d-carbamoylase derived from Nitratireductor indicus (Ni HyuC) …

Biopolymers produced from plant sources offer sustainable alternatives to plastics derived
from petrochemicals. Hydroxylated fatty acids (OHFAs) can be readily polymerized to form …

Mitochondrial cytochromes P450 presumably originated from a common microsomal P450
ancestor. However, it is still unknown how ancient mitochondrial P450s were able to retain …

Ene reductases (EREDs) are enzymes that catalyze the asymmetric reduction of C═ C
bonds. EREDs are potentially useful in the large-scale synthesis of pharmaceutical …

Cytochrome P450 monooxygenases (CYP450s) play an important role in the biosynthesis of
natural products by activating inert C–H bonds and inserting hydroxyl groups. However, the …

工业酶是绿色生物制造的“芯片”, 支撑着下游数十倍甚至百倍的产业. 解析工业酶结构与功能关系
是对其设计改造并应用于工业生产的基础. 近年来随着蛋白结构解析技术和计算模拟技术的发展 …